The Substance 2024 Wikipedia. The substance premiered at the 2024 cannes film festival. Demi moore makes a comeback in.

The final transformation in the substance is tragic and horrifying in equal measure and speaks to the overarching themes of the film. When aerobics star elisabeth sparkle (demi moore) is fired on her 50th birthday because of her age, she decides to try a mysterious experimental laboratory substance that promises to deliver a younger, more beautiful version of herself.